Exploration of high dimensional biomedical datasets with low-distortion embeddings The emergence of high-dimensional datasets in biology and medicine creates a need for developing methods of analysis that can discover the structure and intrinsic organization of these datasets. We have developed new methods for constructing, in an unsupervised way, a new low dimensional parametrization of the dataset. Our approach relies on the assumption that the signals of interest can be described by a small number of parameters, in comparison to the large number of degrees of freedom of the original dataset. We illustrate our approach with several brain imaging datasets (EEG and fMRI).