Abstract: Wireless sensor networks have emerged as the enabling technology for a wide spectrum of distributed systems for diagnosis, monitoring, detection and control in environmental, healthcare and military applications. The natures of sensor networks, such as their large-scale and the extreme resource poverty of their individual nodes in terms of energy and processing capability, have raised many new research challenges. In this talk, we address three specific cross-layer problems: sensor querying for networked control systems, dealing with challenges that arise at the intersection of control theory and networking; collaborative and feedback communications, exploiting the capability of sensor cooperation and feedback information; and power allocation in a fading channel via asymptotic queueing analysis of optimal power-delay tradeoff.