Multi-hop wireless networks with nodes capable of multi-packet reception (MPR) are considered. Relations between asymptotic throughput capacity of the network and end-to-end reliability are derived in terms of power and bandwidth resources as well as the MPR capability of the nodes. It is also demonstrated that for spread spectrum networks calculated theoretic throughput and reliability can be closely approached using partitioned CDMA transmission and MPR receivers employing a low-complexity two-stage iterative detection algorithm.