In this talk, we present some recent results on minimizing the end-to-end buffer usage (which corresponds to the end-to-end delay along a flow path) over a multihop wireless network with general topology and with fixed, loop-free routes. We present a class of (backpressure-like) scheduling algorithms called $\alpha\beta$-algorithms, whose parameters can be chosen such that the decay rate function for end-to-end buffer overflow is shown to be arbitrarily close to optimal in the large-buffer regime. Further, we develop variants that have the same asymptotic optimality property, and also provide good performance in the small-buffer regime.