Mixture proportion estimation is the following problem: given a random sample from a distribution $F$, and another random sample from a distribution $H$, find the largest value $v$ such that $F = (1-v) G + v H$, for some distribution G. I will argue that mixture proportion estimation can be applied to several problems in machine learning where class labels are uncertain or unavailable, including anomaly detection, classification with label noise, classification with sampling bias, classification with reject option, and learning with partial labels.