The classical problem of quickest change detection is studied with an additional constraint on the cost of observations used in the detection process. Bayesian and Minimax formulations are proposed for the problem. It is shown that two-threshold generalizations of the classical single-threshold tests are asymptotically optimal for the proposed formulations. Guidelines are given for the design of the proposed algorithms. Numerical results are provided that reveal that the proposed algorithms have good trade-off curves, and perform significantly better than the approach of fractional sampling, where the constraint on the cost of observations is met by skipping observations randomly. Extensions of this work to sensor networks is also discussed.