We develop a new class of log-Sobolev inequalities (LSIs) that provide a non-linear comparison between the entropy and the Dirichlet form. For the hypercube, these LSIs imply a new (and in essence optimal) version of the hypercontractivity for functions of small support. As a consequence, we derive a sharp form of the uncertainty principle for the hypercube: a function whose energy is concentrated on a set of small size, and whose Fourier energy is concentrated on a small Hamming ball must be zero. The tradeoff we derive is asymptotically optimal. As an application, we show how uncertainty principle implies a new estimate of the metric properties of linear maps $mathbb{F}_2^ktomathbb{F}_2^n$.