We study deregulated power markets with strategic power suppliers. In deregulated markets, each supplier submits its supply function (i.e., the amount of electricity it is willing to produce at various prices) to the independent system operator (ISO), who takes the submitted supply functions as the true marginal cost functions, and dispatches the suppliers to clear the market. If all suppliers reported their true marginal cost functions, the market outcome would be efficient (i.e., the total generation cost is minimized). However, when suppliers are strategic and aim to maximize their own profits, the reported supply functions are not necessarily the marginal cost functions, and the resulting market outcome may be inefficient. The efficiency loss depends crucially on the topology of the underlying transmission network. This paper provides an analytical upper bound of the efficiency loss due to strategic suppliers, and proves that the bound is tight under a large class of transmission networks (i.e., weakly cyclic networks). Our upper bound sheds light on how the efficiency loss depends on the transmission network topology (e.g., the degrees of nodes, the admittances and flow limits of transmission lines).