Under the aegis of the DARPA Molecular Informatics Program a team of Brown chemists and engineers (and others we lure into the fold) hope to discover and implement new ways of thinking about data storage and computation using small molecules (not oligomers like D/RNA). The idea is to understand fundamental limits of molecular storage without oligomers and also seek ways to harness the potentially large parallelism inherent with Avogadrian numbers of miscible reactive elements. This talk will consider initial approaches to both problems.